Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Timeline of the behavioral tests. Each animal completed all behavioral tests, except for Phenotyper that was performed only for a subset of animals: Phenotyper—myoclonus detection; CatWalk—walking pattern (coordination), speed of walk; Startle—startle response, prepulse inhibition; Beam walk—coordination; Elevated plus maze—hyperactivity, speed of walk; Grip strength—strength.

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Inhibition

Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Cstb −/− mice show progressive myoclonus and altered startle response. (A) Myoclonic events were detected in PhenoTyper cages for a period of 3 h at 1.5, 3, and 6 months of age. (B) Progression of myoclonic events from 1.5 to 6 months of age in individual animals (see for separate graphs of Cstb −/− mice). (C) Cstb −/− mice show reduced startle response to 100 dB noise at 3, 5, and 6 months of age compared to the wild type ( wt ) mice. (D–F) Prepulse inhibition (PPI) at 69, 73, and 77 dB prepulse intensities is decreased in Cstb −/− mice at the age of 3 (D) , 5 (E) , and 6 (F) months. Data are presented as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, N = 12 for (A,B) , N = 15–16 for (C–F) .

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Inhibition

Journal: Frontiers in Behavioral Neuroscience

Article Title: In depth behavioral phenotyping unravels complex motor disturbances in Cstb −/− mouse, a model for progressive myoclonus epilepsy type 1

doi: 10.3389/fnbeh.2023.1325051

Figure Lengend Snippet: Comparison of the symptoms in EPM1 patients and in Cstb −/− mice.

Article Snippet: Startle response and prepulse inhibition (PPI) tests were performed using Startle Response (TSE Systems) operating on Startle Response/PPI Version 03.00 software.

Techniques: Comparison, Inhibition

Journal: Progress in neuro-psychopharmacology & biological psychiatry

Article Title: HU-910, a CB2 receptor agonist, reverses behavioral changes in pharmacological rodent models for schizophrenia.

doi: 10.1016/j.pnpbp.2022.110553

Figure Lengend Snippet: Fig. 3. Effects of HU-910 pretreatment on MK-801 and amphetamine-induced PPI disruption. (A) The disruptive effect of MK-801 treatment (0.25 mg/kg) in the PPI was attenuated by HU-910 (30 mg/kg) in all prepulse intensities. *p < 0.05 compared to vehicle+saline group (n = 9/group). (B) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment (C). Effect of HU-910 pretreatment on amphetamine-induced PPI disruption. The disruptive effect of amphetamine treatment (5 mg/kg) in the PPI was attenuated by HU-910 treatment at all doses tested on 80 dB prepulse intensity. On 85 dB and 90 dB prepulse intensities, HU-910 pretreatment attenuated PPI disruption only ate the dose of 3 mg/kg *p < 0.05 compared to vehicle+saline group (n = 10/group). (D) The startle response amplitude (pulse-only trials, arbitrary units, AU) was not modified by any treatment. Repeated-measures ANOVA followed by Turkey's test.

Article Snippet: The prepulse inhibition (PPI) test was performed simultaneously on two identical startle response systems (Med Associates, USA) with a constant 65 dB background noise.

Techniques: Disruption, Saline, Modification